About US

Unify Pharmaceuticals is a biotech company utilizing the latest scientific discoveries to develop drugs targeting neurodegenerative diseases such as Parkinson’s Disease, Myocardial Infarction, Macular Degeneration, Alzheimer’s and Strokes. The company is the culmination of over 20 years’ research into UP-1007, the first-in-class water-soluble fullerene that has been shown to successfully target the underlying causes of Parkinson’s and other diseases involving oxidative damage. The science behind Unify has been supported by more than $39M USD in funding from federal grants and philanthropic gifts

Unify is led by some of the brightest scientific minds in the world with a proven record of creating and developing the world’s most successful drugs:

Prof Laura Dugan – a neuroscientist at Vanderbilt University in Nashville, Tennessee, whose work on neurodegenerative diseases over the past two decades forms the basis for Unify’s business. A physician-scientist, Dugan has studied at some of the top scientific institutions in the world including MIT and Stanford.

Prof Sir Marc Feldmann – has initiated a major revolution in therapeutics; he initiated and developed the first successful monoclonal antibody therapy, anti-TNF.

Prof Sir Marc Feldmann’s Unique Role in Drug Development

In 1990 Prof Sir Marc Feldmann visited Centocor to present the rationale for blocking TNF in rheumatoid arthritis. Reluctantly, they helped him and Sir Ravinder Maini test this with their antibody, now Infliximab (Remicade). The resulting success led to Centocor’s $4.9 B USD acquisition by Johnson & Johnson in 1999. Infliximab is now one of the world’s best-selling drugs, with sales of $7.152 B USD in 2017.

Feldmann and Maini are credited with creating the whole class of anti-TNF drugs. Several other companies used their pioneering research to underpin their own clinical trials.

History

Prof Sir Marc Feldmann

1983

Publishes his hypothesis highlighting the role of cytokines in autoimmune diseases

1983
1984

Begins collaborating with Ravinder S. Maini on rheumatoid arthritis research

1984
1988

Published that anti-TNF normalized joint inflammation in vitro (Brennan et al, Lancet 1988)

1988
1992

 

First successful trials of Infliximab

1992
1999

Infliximab (Remicade) approved and released to the market


Centocor acquired by J&J for $4.9 B USD

1999
2000

Awarded the Crafoord prize with Maini for their work on anti-TNF therapy

2000
2003

Awarded the Albert Lasker award for Clinical Medical Research

2003
2004

Awarded the Cameron Prize for Therapeutics from the University of Edinburgh

2004
2006

Elected a fellow of the Royal Society

2006
2007

Awarded “European Inventor of the Year” by the European Patent Offices

2007
2010

Knighted by Prince Charles in the Queen’s Birthday Honours

2010
2014

Sir Marc Feldmann receives the Canada Gairdner International Award which is the highest scientific award in Canada

2014
2017

Remicade is the seventh-best-selling drug in the world with sales of $7.152 B USD

2017

Prof Laura Dugan

1981

1981
Graduates from MIT, having begun work on graphite composite materials

1981
1987

Completes MD at Ohio State University

1987
1990

Begins clinical training & research on neurodegenerative diseases at Stanford University

1990
1993

Funding by the National Institute of Health begins

1993
1994

Joins Washington University, St Louis

1994
1997

First work published on the neuroprotective properties of UP-1007

1997
2005

First physician-scientist named as Chair in Geriatrics at UCSD

2005
2014

Named head of Division of Geriatric Medicine at Vanderbilt

2014
2015

Meets Prof Sir Marc Feldmann at the University of Oxford

2015
2019

Prof Dugan has received approx. $39 M USD in funding in Federal NIH and DoD grants, one SBIR, and several large philanthropic gifts

2019